Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

The TRPV1 ion channel serves as an integrator of noxious stimuli with its activation linked to pain and neurogenic inflammation. Cholesterol, a major component of cell membranes, modifies the function of several types of ion channels. Here, using measurements of capsaicin-activated currents in excis...

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Bibliographic Details
Main Authors: Picazo-Juárez, Giovanni, Romero-Suárez, Silvina, Nieto-Posadas, Andrés, Llorente, Itzel, Jara-Oseguera, Andrés, Briggs, Margaret, McIntosh, Thomas J., Simon, Sidney A., Ladrón-de-Guevara, Ernesto, Islas, León D., Rosenbaum, Tamara
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137070/
https://ncbi.nlm.nih.gov/pubmed/21555515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237537
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