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Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

Krüppel-like factors (KLFs) control cell differentiation and embryonic development. KLF1 (erythroid Krüppel-like factor) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β-globin genes. KLF1 and KLF2 have highly homologous zin...

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Autori principali: Alhashem, Yousef N., Vinjamur, Divya S., Basu, Mohua, Klingmüller, Ursula, Gaensler, Karin M. L., Lloyd, Joyce A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137057/
https://ncbi.nlm.nih.gov/pubmed/21610079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247536
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