Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes

CS-0777 is a selective sphingosine 1-phosphate (S1P) receptor 1 modulator with potential benefits in the treatment of autoimmune diseases, including multiple sclerosis. CS-0777 is a prodrug that requires phosphorylation to an active S1P analog, similar to the first-in-class S1P receptor modulator FT...

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Detalhes bibliográficos
Main Authors: Yonesu, Kiyoaki, Kubota, Kazuishi, Tamura, Masakazu, Inaba, Shin-ichi, Honda, Tomohiro, Yahara, Chizuko, Watanabe, Nobuaki, Matsuoka, Tatsuji, Nara, Futoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137052/
https://ncbi.nlm.nih.gov/pubmed/21613209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217299
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