Discovery of CS-0777: A Potent, Selective, and Orally Active S1P(1) Agonist

[Image: see text] CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P(1)) modulator. We report herein the synthesis of CS-0777 and CS-0777-P, pharmacological effects such as S1P(1) and S1P(3) agonist activity in vitro, periphera...

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Detalhes bibliográficos
Main Authors: Nishi, Takahide, Miyazaki, Shojiro, Takemoto, Toshiyasu, Suzuki, Keisuke, Iio, Yukiko, Nakajima, Katsuyoshi, Ohnuki, Takashi, Kawase, Yumi, Nara, Futoshi, Inaba, Shinichi, Izumi, Takashi, Yuita, Hiroshi, Oshima, Keiko, Doi, Hiromi, Inoue, Ryotaku, Tomisato, Wataru, Kagari, Takashi, Shimozato, Takaichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017972/
https://ncbi.nlm.nih.gov/pubmed/24900318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100301k
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