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Impaired Infectivity of Ritonavir-resistant HIV Is Rescued by Heat Shock Protein 90AB1
Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease. Analysis of the mutant virus phenotype indicates that accumulation of capsid-spacer peptide 1 precursor protein in virus particles impairs HIV infectivity and that the protea...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137033/ https://ncbi.nlm.nih.gov/pubmed/21602280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248021 |
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