Inhibition of Heat Shock Protein 90 Prevents HIV Rebound

HIV evades eradication because transcriptionally dormant proviral genomes persist in long-lived reservoirs of resting CD4(+) T cells and myeloid cells, which are the source of viral rebound after cessation of antiretroviral therapy. Dormant HIV genomes readily produce infectious virus upon cellular...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Joshi, Pheroze, Maidji, Ekaterina, Stoddart, Cheryl A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858980/
https://ncbi.nlm.nih.gov/pubmed/26957545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717538
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