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Therapeutics Development in Myotonic Dystrophy Type I
Myotonic dystrophy (DM1), the most common adult muscular dystrophy, is a multi-system, autosomal dominant genetic disorder caused by an expanded CTG repeat that leads to nuclear retention of a mutant RNA and subsequent RNA toxicity. Significant insights into the molecular mechanisms of RNA toxicity...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136655/ https://ncbi.nlm.nih.gov/pubmed/21607985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.22090 |
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