Development of potent μ and δ opioid agonists with high lipophilicity

An SAR study on the Dmt-substituted enkephalin-like tetrapeptide with a N-phenyl-N-piperidin-4-yl propionamide moiety at C-terminal was performed, and has resulted in highly potent ligands at μ and δ opioid receptors. In general, ligands with the substitution of D-Nle(2) and halogenation of the arom...

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Bibliografiske detaljer
Main Authors: Lee, Yeon Sun, Kulkarani, Vinod, Cowell, Scott M., Ma, Shou-wu, Davis, Peg, Hanlon, Katherine E., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Vardanyan, Ruben, Hruby, Victor J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136578/
https://ncbi.nlm.nih.gov/pubmed/21128594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100982d
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