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Biodistribution and Pharmacokinetic Analysis of Combination Lonidamine and Paclitaxel Delivery in an Orthotopic Animal Model of Multi-drug Resistant Breast Cancer Using EGFR-Targeted Polymeric Nanoparticles

The aim of this study was to assess the biodistribution and pharmacokinetics of epidermal growth factor receptor (EGFR)-targeted polymer blend nanoparticles loaded with the anticancer drugs lonidamine and paclitaxel. Plasma, tumor, and tissue distribution profiles were quantified in an orthotopic an...

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Detalhes bibliográficos
Main Authors: Milane, Lara, Duan, Zhen-feng, Amiji, Mansoor
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136558/
https://ncbi.nlm.nih.gov/pubmed/21220050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2010.12.009
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