Failure of CD4 T-Cells to Respond to Liver-Derived Antigen and to Provide Help to CD8 T-Cells

CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence. Little is known about priming of CD4 T-cells by liver-derived antigen. We used TF-OVA mice...

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Main Authors: Derkow, Katja, Müller, Anja, Eickmeier, Ira, Seidel, Daniel, Rust Moreira, Marcos Vicinius, Kruse, Nils, Klugewitz, Katja, Mintern, Justine, Wiedenmann, Bertram, Schott, Eckart
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136477/
https://ncbi.nlm.nih.gov/pubmed/21779338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021847
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