Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies

The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90%...

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Main Authors: Penna-Coutinho, Julia, Cortopassi, Wilian Augusto, Oliveira, Aline Alves, França, Tanos Celmar Costa, Krettli, Antoniana Ursine
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136448/
https://ncbi.nlm.nih.gov/pubmed/21779323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021237
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