Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies

The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90%...

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Bibliografski detalji
Glavni autori: Penna-Coutinho, Julia, Cortopassi, Wilian Augusto, Oliveira, Aline Alves, França, Tanos Celmar Costa, Krettli, Antoniana Ursine
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136448/
https://ncbi.nlm.nih.gov/pubmed/21779323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021237
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