Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites

Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index). However, CQ is no longer used alone to treat patients with Plasmodium falciparum due to the emergence and spread of CQ-resistant strains, also reported for P. vivax. Despite CQ resist...

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Autores principales: Aguiar, Anna Caroline Campos, Santos, Raquel de Meneses, Figueiredo, Flávio Júnior Barbosa, Cortopassi, Wilian Augusto, Pimentel, André Silva, França, Tanos Celmar Costa, Meneghetti, Mario Roberto, Krettli, Antoniana Ursine
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359361/
https://ncbi.nlm.nih.gov/pubmed/22649514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037259
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