Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

BACKGROUND: Given the threat of resistance of human malaria parasites, including to artemisinin derivatives, new agents are needed. Chloroquine (CQ) has been the most widely used anti-malarial, and new analogs (CQAns) presenting alkynes and side chain variations with high antiplasmodial activity wer...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: de Souza, Nicolli B, Carmo, Arturene ML, da Silva, Adilson D, França, Tanos CC, Krettli, Antoniana U
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265395/
https://ncbi.nlm.nih.gov/pubmed/25440372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-469
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