Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

BACKGROUND: Given the threat of resistance of human malaria parasites, including to artemisinin derivatives, new agents are needed. Chloroquine (CQ) has been the most widely used anti-malarial, and new analogs (CQAns) presenting alkynes and side chain variations with high antiplasmodial activity wer...

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書目詳細資料
發表在:Malar J
Main Authors: de Souza, Nicolli B, Carmo, Arturene ML, da Silva, Adilson D, França, Tanos CC, Krettli, Antoniana U
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
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Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265395/
https://ncbi.nlm.nih.gov/pubmed/25440372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-469
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