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Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation

The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production o...

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Bibliografski detalji
Glavni autori: Apcher, Sebastien, Daskalogianni, Chrysoula, Lejeune, Fabrice, Manoury, Bénédicte, Imhoos, Gabriela, Heslop, Lea, Fåhraeus, Robin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136330/
https://ncbi.nlm.nih.gov/pubmed/21709220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104104108
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