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Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
PlGF, one of the ligands for VEGFR-1, has been implicated in tumor angiogenesis. However, more recent studies indicate that genetic or pharmacological inhibition of PlGF signaling does not result in reduction of microvascular density in a variety of tumor models. Here we screened 12 human tumor cell...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136309/ https://ncbi.nlm.nih.gov/pubmed/21709213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109029108 |
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