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Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

Combination regimens that include artemisinin derivatives are recommended as first line antimalarials in most countries where malaria is endemic. However, the mechanism of action of artemisinin is not fully understood and the usefulness of this drug class is threatened by reports of decreased parasi...

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Detalles Bibliográficos
Main Authors: Klonis, Nectarios, Crespo-Ortiz, Maria P., Bottova, Iveta, Abu-Bakar, Nurhidanatasha, Kenny, Shannon, Rosenthal, Philip J., Tilley, Leann
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136263/
https://ncbi.nlm.nih.gov/pubmed/21709259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104063108
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