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Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

Combination regimens that include artemisinin derivatives are recommended as first line antimalarials in most countries where malaria is endemic. However, the mechanism of action of artemisinin is not fully understood and the usefulness of this drug class is threatened by reports of decreased parasi...

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Autors principals: Klonis, Nectarios, Crespo-Ortiz, Maria P., Bottova, Iveta, Abu-Bakar, Nurhidanatasha, Kenny, Shannon, Rosenthal, Philip J., Tilley, Leann
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136263/
https://ncbi.nlm.nih.gov/pubmed/21709259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104063108
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