Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)

The platelet-tethering function of von Willebrand factor (VWF) is proteolytically regulated by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), which cleaves the Tyr1605-Met1606 (P1-P1′) bond in the VWF A2 domain. To date, most of the functional interacti...

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Bibliographic Details
Main Authors: Xiang, Yaozu, de Groot, Rens, Crawley, James T. B., Lane, David A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136259/
https://ncbi.nlm.nih.gov/pubmed/21705658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018559108
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