A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage structure and function. ADAMTS-5 is the major aggrecanase in mouse cartilage, and is also likely to be the major aggrecanase in humans. ADAMTS-5 i...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kosasih, Hansen J., Last, Karena, Rogerson, Fraser M., Golub, Suzanne B., Gauci, Stephanie J., Russo, Vincenzo C., Stanton, Heather, Wilson, Richard, Lamande, Shireen R., Holden, Paul, Fosang, Amanda J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751368/
https://ncbi.nlm.nih.gov/pubmed/26668318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704817
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