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Synthesis and Evaluation of Multivalent Branched HPMA Copolymer–Fab′ Conjugates Targeted to the B-Cell Antigen CD20

Several drug delivery designs combine synthetic drug carriers with covalently conjugated targeting moieties. Such modifications of monoclonal antibodies (mAb), or their Fab′ fragments, inevitably result in diminished affinity for their targeted tissue. In an attempt to overcome this limitation, high...

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書目詳細資料
Main Authors: Johnson, Russell N., Kopečková, Pavla, Kopeček, Jindřich
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136133/
https://ncbi.nlm.nih.gov/pubmed/19154157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800351m
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