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Synthesis and Evaluation of Multivalent Branched HPMA Copolymer–Fab′ Conjugates Targeted to the B-Cell Antigen CD20
Several drug delivery designs combine synthetic drug carriers with covalently conjugated targeting moieties. Such modifications of monoclonal antibodies (mAb), or their Fab′ fragments, inevitably result in diminished affinity for their targeted tissue. In an attempt to overcome this limitation, high...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136133/ https://ncbi.nlm.nih.gov/pubmed/19154157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800351m |
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