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Synthesis and Evaluation of Multivalent Branched HPMA Copolymer–Fab′ Conjugates Targeted to the B-Cell Antigen CD20

Several drug delivery designs combine synthetic drug carriers with covalently conjugated targeting moieties. Such modifications of monoclonal antibodies (mAb), or their Fab′ fragments, inevitably result in diminished affinity for their targeted tissue. In an attempt to overcome this limitation, high...

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Bibliografske podrobnosti
Main Authors: Johnson, Russell N., Kopečková, Pavla, Kopeček, Jindřich
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136133/
https://ncbi.nlm.nih.gov/pubmed/19154157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800351m
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