HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of T(H)17 and T(reg) cells

Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the resting state. Although a role for the metabolic switch to glycolysis has been suggested to support increased anabolic activities and facilitate T cell growth and proliferation, whether cellular metabolism c...

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Detalhes bibliográficos
Main Authors: Shi, Lewis Z., Wang, Ruoning, Huang, Gonghua, Vogel, Peter, Neale, Geoffrey, Green, Douglas R., Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135370/
https://ncbi.nlm.nih.gov/pubmed/21708926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110278
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