Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies

The HIV-1 envelope trimer adopts a quaternary conformation that effectively shields neutralization-sensitive domains and thus represents a major obstacle for natural and vaccine-elicited antibody responses. By using a structure–function analysis based on a specifically devised mathematical model, we...

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Main Authors: Rusert, Peter, Krarup, Anders, Magnus, Carsten, Brandenberg, Oliver F., Weber, Jacqueline, Ehlert, Anna-Katharina, Regoes, Roland R., Günthard, Huldrych F., Trkola, Alexandra
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135368/
https://ncbi.nlm.nih.gov/pubmed/21646396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110196
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