Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells

Sustained long-term antibody levels are the cornerstone of protective immunity, yet it remains unclear how they are durably maintained. A predominant theory implicates antigen-independent antibody production by a subset of long-lived plasma cells (LLPCs) that survive within bone marrow (BM). Central...

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Detalhes bibliográficos
Main Authors: Rozanski, Cheryl H., Arens, Ramon, Carlson, Louise M., Nair, Jayakumar, Boise, Lawrence H., Chanan-Khan, Asher A., Schoenberger, Stephen P., Lee, Kelvin P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135367/
https://ncbi.nlm.nih.gov/pubmed/21690252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110040
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