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Immunological characterization of papain-induced fragments of Clostridium botulinum type A neurotoxin and interaction of the fragments with brain synaptosomes.

After treatment of Clostridium botulinum type A neurotoxin with papain, three fragments (Mrs, 101,000, 45,000, and 43,000) were purified by hydrophobic and ion-exchange chromatography with a high-performance liquid chromatographic system. Immunoblotting analyses with monoclonal antibodies showed tha...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Kozaki, S, Miki, A, Kamata, Y, Ogasawara, J, Sakaguchi, G
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1989
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313505/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2668181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.9.2634-2639.1989
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