Bioadhesive Microspheres for Bioavailability Enhancement of Raloxifene Hydrochloride: Formulation and Pharmacokinetic Evaluation

Raloxifene hydrochloride (R-HCl), a BCS class II drug, remains a mainstay in the prevention and pharmacologic therapy of osteoporosis. Its absolute bioavailability, however, is 2% due to poor solubility and extensive first pass metabolism. The present study describes two simultaneous approaches to i...

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Bibliographic Details
Main Authors: Jha, Ram K., Tiwari, Sanjay, Mishra, Brahmeshwar
Format: Artigo
Language:Inglês
Published: Springer US 2011
Subjects:
Research Article Theme: Advanced Technologies for Oral Controlled Release Guest Editors: Michael Repka, Joseph Reo, Linda Felton, and Stephen Howard
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134648/
https://ncbi.nlm.nih.gov/pubmed/21562721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9619-9
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