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Hierarchical Commensurate and Power Prior Models for Adaptive Incorporation of Historical Information in Clinical Trials

Bayesian clinical trial designs offer the possibility of a substantially reduced sample size, increased statistical power, and reductions in cost and ethical hazard. However when prior and current information conflict, Bayesian methods can lead to higher than expected Type I error, as well as the po...

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Autors principals: Hobbs, Brian P., Carlin, Bradley P., Mandrekar, Sumithra J., Sargent, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134568/
https://ncbi.nlm.nih.gov/pubmed/21361892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1541-0420.2011.01564.x
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