Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

TET-family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Here we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain 5hmC in mouse embryonic stem (ES) cells, and are induced concomitantly with 5hmC during reprogramming of fibroblasts to induced...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Koh, Kian Peng, Yabuuchi, Akiko, Rao, Sridhar, Huang, Yun, Cunniff, Kerrianne, Nardone, Julie, Laiho, Asta, Tahiliani, Mamta, Sommer, Cesar A., Mostoslavsky, Gustavo, Lahesmaa, Riitta, Orkin, Stuart H., Rodig, Scott J., Daley, George Q., Rao, Anjana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134318/
https://ncbi.nlm.nih.gov/pubmed/21295276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.01.008
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