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Mutants of the Base Excision Repair Glycosylase, Endonuclease III: DNA Charge Transport as a First Step in Lesion Detection

Endonuclease III (EndoIII) is a base excision repair glycosylase that targets damaged pyrimidines and contains a [4Fe-4S] cluster. We have proposed a model where BER proteins that contain redox-active [4Fe-4S] clusters utilize DNA charge transport (CT) as a first step in the detection of DNA lesions...

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Библиографические подробности
Главные авторы: Romano, Christine A., Sontz, Pamela A., Barton, Jacqueline K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134277/
https://ncbi.nlm.nih.gov/pubmed/21651304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2003179
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