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Dual blockade of the EGFR and COX-2 pathways: A phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer

OBJECTIVES: The epidermal growth factor receptor and cyclooxygenase-2 pathways play key and often complementary roles in the pathogenesis of colorectal cancer (CRC). This study explores the clinical and biological effects of combined blockade of these pathways METHODS: Cetuximab-naive patients with...

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Detalhes bibliográficos
Main Authors: Chan, Emily, LaFleur, Bonnie, Rothenberg, Mace L., Merchant, Nipun, Lockhart, A. Craig, Trivedi, Bakula, Chung, Christine H., Coffey, Robert J., Berlin, Jordan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133812/
https://ncbi.nlm.nih.gov/pubmed/21217396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0b013e3181fe46a1
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