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Stat3 Phosphorylation Mediates Resistance of Primary Human T Cells to Regulatory T Cell Suppression

Human autoimmune diseases are characterized by systemic T cell dysfunction, resulting in chronically activated Th1 and Th17 cells that are inadequately suppressed by regulatory T cells (Tregs). IL-6, which is overexpressed in tissue and serum of patients with autoimmune diseases, inhibits human Treg...

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Detalhes bibliográficos
Main Authors: Goodman, Wendy A., Young, Andrew B., McCormick, Thomas S., Cooper, Kevin D., Levine, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133678/
https://ncbi.nlm.nih.gov/pubmed/21307288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001455
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