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Ptf1a and Nkx6 transcription factors function as antagonistic lineage determinants in multipotent pancreatic progenitors

The molecular mechanisms that underlie cell lineage diversification of multipotent progenitors in the pancreas are virtually unknown. Here, we show that the early fate choice of pancreatic progenitors between the endocrine and acinar cell lineage is restricted by cross-repressive interactions betwee...

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Sonraí Bibleagrafaíochta
Main Authors: Schaffer, Ashleigh E., Freude, Kristine K., Nelson, Shelley B., Sander, Maike
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133668/
https://ncbi.nlm.nih.gov/pubmed/20627083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.05.015
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