S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

Down syndrome (DS) is a developmental disorder associated with mental retardation (MR) and early onset Alzheimer's disease (AD). These CNS phenotypes are attributed to ongoing neuronal degeneration due to constitutive overexpression of chromosome 21 (HSA21) genes. We have previously shown that...

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Détails bibliographiques
Auteurs principaux: Lu, Jie, Esposito, Giuseppe, Scuderi, Caterina, Steardo, Luca, Delli-Bovi, Laurent C., Hecht, Jonathan L., Dickinson, Bryan C., Chang, Christopher J., Mori, Takashi, Sheen, Volney
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133657/
https://ncbi.nlm.nih.gov/pubmed/21779383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022126
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