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Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-Induced Ca(2+) Influx and Mitochondrial Reactive Oxygen Generation
DRAK2 is a serine/threonine kinase highly enriched in lymphocytes that raises the threshold for T cell activation and maintains T cell survival following productive activation. T cells lacking DRAK2 are prone to activation under suboptimal conditions and exhibit enhanced calcium responses to AgR sti...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133617/ https://ncbi.nlm.nih.gov/pubmed/21148796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000942 |
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