THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE-STRESS-ADAPTIVE PROTEOLYTIC COMPLEXES

Oxidized cytoplasmic and nuclear proteins are normally degraded by proteasome, but accumulate with age and disease. We demonstrate the importance of various forms of the proteasome during transient (reversible) adaptation (hormesis), to oxidative stress in murine embryonic fibroblasts. Adaptation wa...

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Autori principali: Pickering, Andrew M., Koop, Alison L., Teoh, Cheryl Y., Ermak, Gennady, Grune, Tilman, Davies, Kelvin J. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133595/
https://ncbi.nlm.nih.gov/pubmed/20919990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100878
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