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Disruption of Leptin Receptor-STAT3 Signaling Enhances Leukotriene Production and Pulmonary Host Defense against Pneumococcal Pneumonia

The adipocyte-derived hormone, leptin, regulates energy homeostasis and the innate immune response. We previously reported that leptin plays a protective role in bacterial pneumonia, but the mechanisms by which leptin regulates host defense remain poorly understood. Leptin binding to its receptor, L...

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מידע ביבליוגרפי
Main Authors: Mancuso, Peter, Peters-Golden, Marc, Goel, Deepti, Goldberg, Jared, Brock, Thomas G., Greenwald-Yarnell, Megan, Myers, Martin G.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133444/
https://ncbi.nlm.nih.gov/pubmed/21148797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001470
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