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Disruption of Leptin Receptor-STAT3 Signaling Enhances Leukotriene Production and Pulmonary Host Defense against Pneumococcal Pneumonia
The adipocyte-derived hormone, leptin, regulates energy homeostasis and the innate immune response. We previously reported that leptin plays a protective role in bacterial pneumonia, but the mechanisms by which leptin regulates host defense remain poorly understood. Leptin binding to its receptor, L...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133444/ https://ncbi.nlm.nih.gov/pubmed/21148797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001470 |
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