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Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3

Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming cle...

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Main Authors: Gamsjaeger, Roland, Webb, Sarah R., Lamonica, Janine M., Billin, Andrew, Blobel, Gerd A., Mackay, Joel P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133386/
https://ncbi.nlm.nih.gov/pubmed/21555453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05413-11
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