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Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3

Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming cle...

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Autori principali: Gamsjaeger, Roland, Webb, Sarah R., Lamonica, Janine M., Billin, Andrew, Blobel, Gerd A., Mackay, Joel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133386/
https://ncbi.nlm.nih.gov/pubmed/21555453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05413-11
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