Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends

Double-strand breaks (DSBs) in chromosomal DNA elicit a rapid signaling response through the ATM protein kinase. ATM corresponds to Tel1 in budding yeast. Here we show that the catalytic activity of Tel1 is altered by protein binding at DNA ends via the Mre11-Rad50-Xrs2 (MRX) complex. Like ATM, Tel1...

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Bibliographic Details
Main Authors: Fukunaga, Kenzo, Kwon, Youngho, Sung, Patrick, Sugimoto, Katsunori
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133365/
https://ncbi.nlm.nih.gov/pubmed/21402778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05157-11
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