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Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends
Double-strand breaks (DSBs) in chromosomal DNA elicit a rapid signaling response through the ATM protein kinase. ATM corresponds to Tel1 in budding yeast. Here we show that the catalytic activity of Tel1 is altered by protein binding at DNA ends via the Mre11-Rad50-Xrs2 (MRX) complex. Like ATM, Tel1...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133365/ https://ncbi.nlm.nih.gov/pubmed/21402778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05157-11 |
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