Nuclear but Not Cytosolic Phosphoinositide 3-Kinase Beta Has an Essential Function in Cell Survival

Class I(A) phosphoinositide 3-kinases (PI3Ks) are heterodimeric enzymes composed of a p85 regulatory and a p110 catalytic subunit that induce the formation of 3-polyphosphoinositides, which mediate cell survival, division, and migration. There are two ubiquitous PI3K isoforms p110α and p110β that ha...

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Bibliographic Details
Main Authors: Kumar, Amit, Redondo-Muñoz, Javier, Perez-García, Vicente, Cortes, Isabel, Chagoyen, Monica, Carrera, Ana C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133359/
https://ncbi.nlm.nih.gov/pubmed/21383062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01313-10
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