Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type...

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Bibliografiske detaljer
Main Authors: Kang, Hong Soon, Okamoto, Kyoko, Takeda, Yukimasa, Beak, Ju Youn, Gerrish, Kevin, Bortner, Carl D., DeGraff, Laura M., Wada, Taira, Xie, Wen, Jetten, Anton M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132837/
https://ncbi.nlm.nih.gov/pubmed/21540300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00206.2010
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