Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

OBJECTIVE: The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. In this study, we investigate whether TAK1 functions as a regulator of lipid and energy homeostasis and has a role in metabolic syndrome. RESEARCH DESIGN AND METHOD...

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Main Authors: Kang, Hong Soon, Okamoto, Kyoko, Kim, Yong-Sik, Takeda, Yukimasa, Bortner, Carl D., Dang, Huaixin, Wada, Taira, Xie, Wen, Yang, Xiao-Ping, Liao, Grace, Jetten, Anton M.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Obesity Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012170/
https://ncbi.nlm.nih.gov/pubmed/20864514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0628
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