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Absence of Vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and anti-viral immunity in mice

Vasoactive intestinal peptide (VIP) induces regulatory dendritic cells (DC) in vitro that inhibit cellular immune responses. We tested the role of physiological levels of VIP on immune responses to murine cytomegalovirus (mCMV) using VIP-knockout (VIP-KO) mice and radiation chimeras engrafted with s...

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Autori principali: Li, Jian-Ming, Southerland, Lauren, Hossain, Mohammad S., Giver, Cynthia R., Wang, Ying, Darlak, Kasia, Harris, Wayne, Waschek, James, Waller, Edmund K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132578/
https://ncbi.nlm.nih.gov/pubmed/21677142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100686
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