A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function

RATIONALE: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-282 and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest the nonequivalence of these sites and the potential importance of Ser-282 phosphorylation in modulating the protein'...

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Autors principals: Sadayappan, Sakthivel, Gulick, James, Osinska, Hanna, Barefield, David, Cuello, Friederike, Avkiran, Metin, Lasko, Valerie M., Lorenz, John N., Maillet, Marjorie, Martin, Jody L., Brown, Joan Heller, Bers, Donald M., Molkentin, Jeffery D., James, Jeanne, Robbins, Jeffrey
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132348/
https://ncbi.nlm.nih.gov/pubmed/21597010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.242560
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