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Mutating the dileucine motif of the human β(2)-adrenoceptor reduces the high initial rate of receptor phosphorylation by GRK without affecting postendocytic sorting
The internalization of β(2)-adrenoceptors after agonist activation results in a desensitized and phosphorylated receptor that either resensitizes by recycling to the cell surface or becomes degraded by postendocytic sorting to lysosomes. The duration and physiological effects of agonists therefore d...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3132186/ https://ncbi.nlm.nih.gov/pubmed/20193676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.02.033 |
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