The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage

Apaf1 is a key regulator of the mitochondrial intrinsic pathway of apoptosis, as it activates executioner caspases by forming the apoptotic machinery apoptosome. Its genetic regulation and its post-translational modification are crucial under the various conditions where apoptosis occurs. Here we de...

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Autors principals: De Zio, D, Bordi, M, Tino, E, Lanzuolo, C, Ferraro, E, Mora, E, Ciccosanti, F, Fimia, G M, Orlando, V, Cecconi, F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132004/
https://ncbi.nlm.nih.gov/pubmed/20966962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.125
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