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The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage
Apaf1 is a key regulator of the mitochondrial intrinsic pathway of apoptosis, as it activates executioner caspases by forming the apoptotic machinery apoptosome. Its genetic regulation and its post-translational modification are crucial under the various conditions where apoptosis occurs. Here we de...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3132004/ https://ncbi.nlm.nih.gov/pubmed/20966962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.125 |
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