Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

A mutation within one allele of the p53 tumor suppressor gene can inactivate the remaining wild-type allele in a dominant-negative manner and in some cases can exert an additional oncogenic activity, known as mutant p53 ‘gain of function' (GOF). To study the role of p53 mutations in prostate ca...

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Detalhes bibliográficos
Main Authors: Kogan-Sakin, I, Tabach, Y, Buganim, Y, Molchadsky, A, Solomon, H, Madar, S, Kamer, I, Stambolsky, P, Shelly, A, Goldfinger, N, Valsesia-Wittmann, S, Puisieux, A, Zundelevich, A, Gal-Yam, E N, Avivi, C, Barshack, I, Brait, M, Sidransky, D, Domany, E, Rotter, V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131887/
https://ncbi.nlm.nih.gov/pubmed/20689556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.94
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