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Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin
[Image: see text] Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression, rendering ATX an attracti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131786/ https://ncbi.nlm.nih.gov/pubmed/21615078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200310q |
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