Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin

[Image: see text] Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression, rendering ATX an attracti...

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Bibliografiske detaljer
Main Authors: Albers, Harald M. H. G., Hendrickx, Loes J. D., van Tol, Rob J. P., Hausmann, Jens, Perrakis, Anastassis, Ovaa, Huib
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131786/
https://ncbi.nlm.nih.gov/pubmed/21615078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200310q
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